Anti-Nanog (IHC)

Anti-Nanog (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00205-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00205 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Transcription regulator involved in inner cell mass and embryonic stem (ES)... more
Product information "Anti-Nanog (IHC)"
Protein function: Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal (PubMed:25825768). Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'- [CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation. [The UniProt Consortium]
Keywords: Anti-Nanog, Anti-Ecat4, Anti-Homeobox protein NANOG, Anti-ES cell-associated protein 4, Anti-Homeobox transcription factor Nanog, Anti-Early embryo specific expression NK-type homeobox protein
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00205

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: mouse (Expected: japanese house mouse)
Immunogen: synthetic peptide. The epitope recognized by IHC-00205 maps to a region between residues 1 and 50 of mouse Nanog homeobox using the numbering given in TrEMBL entry Q80Z64 (GeneID 71950).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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