Anti-RIF1 (IHC)

Anti-RIF1 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00203-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00203 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Key regulator of TP53BP1 that plays a key role in the repair of double-strand... more
Product information "Anti-RIF1 (IHC)"
Protein function: Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)- mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs. Promotes NHEJ of dysfunctional telomeres. [The UniProt Consortium]
Keywords: Anti-Telomere-associated protein RIF1, Anti-Rap1-interacting factor 1 homolog
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00203

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: orangutan, chimpanzee, northern white-cheeked gibbon)
Immunogen: synthetic peptide. The epitope recognized by IHC-00203 maps to a region between residues 2425 and the C-terminus (residue 2472) of human Rap1 Interacting Factor 1 using the numbering given in entry NP_060621.3 (GeneID 55183).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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