Anti-RCH1/KPNA2 (IHC)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00201-T 10 µl (1 µg) -

2 - 8 business days*

164.00€
IHC-00201 100 µl (10 µg) -

2 - 8 business days*

623.00€
 
Protein function: Functions in nuclear protein import as an adapter protein for nuclear receptor... more
Product information "Anti-RCH1/KPNA2 (IHC)"
Protein function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. [The UniProt Consortium]
Keywords: Anti-RCH1, Anti-KPNA2, Anti-SRP1-alpha, Anti-RAG cohort protein 1, Anti-Importin subunit alpha-1, Anti-Karyopherin subunit alpha-2
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00201

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: orangutan, chimpanzee)
Immunogen: synthetic peptide. The epitope recognized by IHC-00201 maps to a region between residues 475 and the C-terminus (residue 529) of human RAG cohort 1 (Karyopherin Alpha 2) using the numbering given in entry NP_002257.1 (GeneID 3838).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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