Anti-SMC6 (IHC)

Anti-SMC6 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00198-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00198 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Core component of the SMC5-SMC6 complex, a complex involved in DNA... more
Product information "Anti-SMC6 (IHC)"
Protein function: Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541). [The UniProt Consortium]
Keywords: Anti-SMC6, Anti-hSMC6, Anti-SMC-6, Anti-SMC6L1, Anti-SMC protein 6, Anti-Structural maintenance of chromosomes protein 6
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00198

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: chimpanzee)
Immunogen: synthetic peptide. The epitope recognized by IHC-00198 maps to a region between residues 1050 and the C-terminus (residue 1091) of human Structural Maintenance of Chromosomes 6 using the numbering given in TrEMBL entry Q96SB8 (GeneID 79677).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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