Anti-NF2 (IHC)

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
IHC-00193-T	10 µl (1 µg)		-		2 - 8 business days*		164.00€
IHC-00193	100 µl (10 µg)		-		2 - 8 business days*		623.00€

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Protein function: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a... more

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Product information "Anti-NF2 (IHC)"

Protein function: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex. [The UniProt Consortium]

Keywords:	Anti-NF2, Anti-SCH, Anti-Merlin, Anti-Schwannomin, Anti-Schwannomerlin, Anti-Neurofibromin-2, Anti-Moesin-ezrin-radixin-like protein
Supplier:	Bethyl Laboratories
Supplier-Nr:	IHC-00193

Properties

Application:	IHC, IHC-IF
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: mouse, rat, bovine, dog, horse, rabbit, pig, panda, orangutan, gorilla, chinese hamster, northern white-cheeked gibbon)
Immunogen:	synthetic peptide. The epitope recognized by IHC-00193 maps to a region between residues 550 and the C-terminus (residue 595) of human Neurofibromin 2 using the numbering given in entry NP_000259.1 (GeneID 4771). This epitope is common to NF2 isoforms 1 and 9 (Mer162).
Format:	Antigen Affinity Purified