Anti-NCOA62 (IHC)

Anti-NCOA62 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00192-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00192 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Involved in transcriptional regulation. Modulates TGF- beta-mediated... more
Product information "Anti-NCOA62 (IHC)"
Protein function: Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. Functions as a splicing factor in pre-mRNA splicing. Is required in the specific splicing of CDKN1A pre-mRNA, the function probably involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. [The UniProt Consortium]
Keywords: Anti-SNW1, Anti-SKIIP, Anti-Nuclear protein SkiP, Anti-Ski-interacting protein, Anti-SNW domain-containing protein 1, Anti-Nuclear receptor coactivator NCoA-62
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00192

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: bovine, dog, horse, rabbit, pig, orangutan, monkey, gorilla, chimpanzee, gray short-tailed opossum, chinese hamster)
Immunogen: synthetic peptide. The epitope recognized by IHC-00192 maps to a region between residues 450 and 500 of human Nuclear Receptor Coactivator, 62 kD (SKIIP, SKI Interacting Protein) using the numbering given in entry NP_036377.1 (GeneID 22938).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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