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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
IHC-00187-T | 10 µl (2500 ng) | - |
2 - 8 business days* |
164.00€
|
|||
IHC-00187 | 100 µl (25 µg) | - |
2 - 8 business days* |
623.00€
|
Protein function: Recruiter that couples transcriptional factors to general transcription... more
Product information "Anti-MCAF (IHC)"
Protein function: Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells. [The UniProt Consortium]
Keywords: | Anti-hAM, Anti-MCAF, Anti-P621, Anti-ATF-IP, Anti-ATF7IP, Anti-ATF-interacting protein, Anti-ATF7-interacting protein, Anti-ATFa-associated modulator, Anti-MBD1-containing chromatin-associated factor 1 |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | IHC-00187 |
Properties
Application: | IHC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse (Expected: bovine, dog, horse, pig, panda, orangutan, monkey, gorilla, chimpanzee, african elephant, crab-eating macaque) |
Immunogen: | synthetic peptide. The epitope recognized by IHC-00187 maps to a region between residues 25 and 100 of human MBD1-containing Chromatin Associated Factor using the numbering given in entry AAQ92978.1 (GeneID 55729). |
Format: | Antigen Affinity Purified |
Database Information
UniProt ID : | Q6VMQ6 | Matching products |
Gene ID | GeneID 55729 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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