Anti-Sin1 (IHC)

Anti-Sin1 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00183-T 10 µl (1 µg) -

2 - 8 business days*

164.00€
IHC-00183 100 µl (10 µg) -

2 - 8 business days*

623.00€
 
Protein function: Subunit of mTORC2, which regulates cell growth and survival in response to... more
Product information "Anti-Sin1 (IHC)"
Protein function: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex. [The UniProt Consortium]
Keywords: Anti-MIP1, Anti-mSIN1, Anti-MAPKAP1, Anti-TORC2 subunit MAPKAP1, Anti-SAPK-interacting protein 1, Anti-Target of rapamycin complex 2 subunit MAPKAP1, Anti-Stress-activated map kinase-interacting protein 1
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00183

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: rat, chicken, turkey, sheep, bovine, dog, horse, guinea pig_10141, pig, panda, orangutan, monkey, gorilla, chimpanzee)
Immunogen: synthetic peptide. The epitope recognized by IHC-00183 maps to a region between residues 470 and the C-terminus (residue 522) of human stress-activated map kinase interacting protein 1 using the numbering given in entry NP_001006618.1 (GeneID 79109).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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