Anti-CSN2 (IHC)

Anti-CSN2 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00179-T 10 µl (1 µg) -

2 - 8 business days*

164.00€
IHC-00179 100 µl (10 µg) -

2 - 8 business days*

623.00€
 
Protein function: Essential component of the COP9 signalosome complex (CSN), a complex involved... more
Product information "Anti-CSN2 (IHC)"
Protein function: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. [The UniProt Consortium]
Keywords: Anti-SGN2, Anti-CSN2, Anti-COPS2, Anti-TRIP-15, Anti-Alien homolog, Anti-Signalosome subunit 2, Anti-TR-interacting protein 15, Anti-COP9 signalosome complex subunit 2, Anti-JAB1-containing signalosome subunit 2
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00179

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: rat, zebrafish, X. laevis, X. tropicalis, chicken, bovine, dog, horse, rabbit, guinea pig_10141, pig, panda, orangutan)
Immunogen: synthetic peptide. The epitope recognized by IHC-00179 maps to a region between residues 1 and 50 of human COP9 constitutive photomorphogenic homolog subunit 2 using the numbering given in entry NP_004227.1 (GeneID 9318).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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