Anti-THRAP3/TRAP150 (IHC)

Anti-THRAP3/TRAP150 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00158-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00158 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Involved in pre-mRNA splicing. Remains associated with spliced mRNA after... more
Product information "Anti-THRAP3/TRAP150 (IHC)"
Protein function: Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition, the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex, however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-ARNTL/BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). [The UniProt Consortium]
Keywords: Anti-THRAP3, Anti-Trap150, Anti-TRAP150, Anti-Thyroid hormone receptor-associated protein 3, Anti-Thyroid hormone receptor-associated protein complex 150 kDa component
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00158

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: orangutan, gorilla, chimpanzee, northern white-cheeked gibbon)
Immunogen: synthetic peptide. The epitope recognized by IHC-00158 maps to a region between residues 905 and the C-terminus (residue 955) of human Thyroid Hormone Receptor Associated Protein 3 (Thyroid Hormone Receptor-Asscociated Protein, 150 kDa) using the numbering given in entry NP
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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