Anti-PPP4C (IHC)

Anti-PPP4C (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00154-T 10 µl (1 µg) -

2 - 8 business days*

164.00€
IHC-00154 100 µl (10 µg) -

2 - 8 business days*

623.00€
 
Protein function: Protein phosphatase that is involved in many processes such as microtubule... more
Product information "Anti-PPP4C (IHC)"
Protein function: Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C- PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase. In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin. [The UniProt Consortium]
Keywords: Anti-Pp4, Anti-PP-X, Anti-PP4C, Anti-PPP4, Anti-PPP4C, EC=3.1.3.16, Anti-Protein phosphatase X, Anti-Serine/threonine-protein phosphatase 4 catalytic subunit
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00154

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: rat, bovine, dog, horse, rabbit, guinea pig_10141, panda, orangutan, monkey, gorilla, chimpanzee, tasmanian devil)
Immunogen: synthetic peptide. The epitope recognized by IHC-00154 maps to a region between residues 1 and 50 of human Protein Phosphatase 4, Catalytic Subunit using the numbering given in entry NP_002711.1 (GeneID 5531).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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