Anti-TIF1 Alpha/TRIM24 (IHC)

Anti-TIF1 Alpha/TRIM24 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00144-T 10 µl (1 µg) -

2 - 8 business days*

164.00€
IHC-00144 100 µl (10 µg) -

2 - 8 business days*

623.00€
 
Protein function: Transcriptional coactivator that interacts with numerous nuclear receptors and... more
Product information "Anti-TIF1 Alpha/TRIM24 (IHC)"
Protein function: Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes. [The UniProt Consortium]
Keywords: Anti-RNF82, Anti-TRIM24, Anti-TIF1-alpha, EC=2.3.2.27, Anti-RING finger protein 82, Anti-E3 ubiquitin-protein ligase TRIM24, Anti-Tripartite motif-containing protein 24, Anti-Transcription intermediary factor 1-alpha
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00144

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: rat, bovine, dog, horse, rabbit, guinea pig_10141, panda, orangutan, monkey, gorilla, chimpanzee, chinese hamster)
Immunogen: synthetic peptide. The epitope recognized by IHC-00144 maps to a region between residues 700 and 750 of human Transcriptional Intermediary Factor 1 Alpha (Tripartite Motif-Containing 24 ) using the numbering given in entry NP_056989.2 (GeneID 8805).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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