Anti-REST (IHC)

Anti-REST (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00141-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00141 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Transcriptional repressor which binds neuron-restrictive silencer element... more
Product information "Anti-REST (IHC)"
Protein function: Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression. [The UniProt Consortium]
Keywords: Anti-REST, Anti-NRSF, Anti-X2 box repressor, Anti-RE1-silencing transcription factor, Anti-Neural-restrictive silencer factor
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00141

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: orangutan, monkey, gorilla, chimpanzee, northern white-cheeked gibbon, crab-eating macaque, white-tufted-ear marmoset)
Immunogen: synthetic peptide. The epitope recognized by IHC-00141 maps to a region between residues 1050 and the C-terminus (residue 1097) of human RE1-silencing transcription factor using the numbering given in entry NP_005603.2 (GeneID 5978).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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