Anti-CSE1 (IHC)

Anti-CSE1 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00138-T 10 µl (1 µg) -

2 - 8 business days*

164.00€
IHC-00138 100 µl (10 µg) -

2 - 8 business days*

623.00€
 
Protein function: Export receptor for importin-alpha. Mediates importin- alpha re-export from the... more
Product information "Anti-CSE1 (IHC)"
Protein function: Export receptor for importin-alpha. Mediates importin- alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. [The UniProt Consortium]
Keywords: Anti-CAS, Anti-Exp2, Anti-CSE1L, Anti-Exportin-2, Anti-Importin-alpha re-exporter, Anti-Chromosome segregation 1-like protein, Anti-Cellular apoptosis susceptibility protein
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00138

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: rat, chicken, turkey, bovine, horse, rabbit, guinea pig_10141, pig, panda, orangutan, monkey, gorilla, chimpanzee)
Immunogen: synthetic peptide. The epitope recognized by IHC-00138 maps to a region between residues 1 and 50 of human Chromosome Segregation-1 using the numbering given in entry NP_001307.2 (GeneID 1434).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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