Anti-CoREST (IHC)

Anti-CoREST (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00136-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00136 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Essential component of the BHC complex, a corepressor complex that represses... more
Product information "Anti-CoREST (IHC)"
Protein function: Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. [The UniProt Consortium]
Keywords: Anti-RCOR1, Anti-KIAA0071, Anti-Protein CoREST, Anti-REST corepressor 1
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00136

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: chimpanzee)
Immunogen: synthetic peptide. The epitope recognized by IHC-00136 maps to a region between residues 425 and the C-terminus (residue 482) of human REST (RE1-silencing transcription factor) corepressor using the numbering given in entry NP_055971.1 (GeneID 23186)
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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