Anti-DBC1/p30 DBC (IHC)

Anti-DBC1/p30 DBC (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00135-T 10 µl (500 ng) -

2 - 8 business days*

164.00€
IHC-00135 100 µl (5 µg) -

2 - 8 business days*

623.00€
 
Protein function: Core component of the DBIRD complex, a multiprotein complex that acts at the... more
Product information "Anti-DBC1/p30 DBC (IHC)"
Protein function: Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3- specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:18235501, PubMed:18235502, PubMed:19131338, PubMed:19218236, PubMed:22446626, PubMed:23352644, PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta- catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation, stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978). [The UniProt Consortium]
Keywords: Anti-DBC1, Anti-CCAR2, Anti-DBC.1, Anti-DBC-1, Anti-NET35, Anti-p30 DBC, Anti-DBIRD complex subunit KIAA1967, Anti-Deleted in breast cancer gene 1 protein, Anti-Cell cycle and apoptosis regulator protein 2
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00135

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: rat, bovine, dog, horse, guinea pig_10141, pig, panda, orangutan, monkey, gorilla, chimpanzee, chinese hamster)
Immunogen: synthetic peptide. The epitope recognized by IHC-00135 maps to a region between residues 1 and 50 of human Deleted in Breast Cancer 1 using the numbering given in TrEMBL entry Q6P0Q9 (GeneID 57805).
Format: Antigen Affinity Purified

Database Information

UniProt ID : Q8N163 | Matching products
Gene ID GeneID 57805 | Matching products

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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