Anti-DDX1 (IHC)

Anti-DDX1 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00132-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00132 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA... more
Product information "Anti-DDX1 (IHC)"
Protein function: Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF- kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation (PubMed:24870230). Required for HIV-1 Rev function as well as for HIV-1 replication. Binds to the RRE sequence of HIV-1 mRNAs. [The UniProt Consortium]
Keywords: Anti-DDX1, Anti-DBP-RB, EC=3.6.4.13, Anti-DEAD box protein 1, Anti-ATP-dependent RNA helicase DDX1, Anti-DEAD box protein retinoblastoma
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00132

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: mouse, rat, bovine, dog, horse, rabbit, guinea pig_10141, pig, panda, orangutan, monkey, gorilla, chimpanzee)
Immunogen: synthetic peptide. The epitope recognized by IHC-00132 maps to a region between residues 500 and 550 of human DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 1 using the numbering given in entry AAH12739.1 (GeneID 1653).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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