Anti-BHC110/LSD1 (IHC)

Anti-BHC110/LSD1 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00122-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00122 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9'... more
Product information "Anti-BHC110/LSD1 (IHC)"
Protein function: Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr- 6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E- cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7. [The UniProt Consortium]
Keywords: Anti-AOF2, Anti-KDM1A, EC=1.-.-.-, Anti-BRAF35-HDAC complex protein BHC110, Anti-Lysine-specific histone demethylase 1A, Anti-Flavin-containing amine oxidase domain-containing protein 2
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00122

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: orangutan, gorilla)
Immunogen: synthetic peptide. The epitope recognized by IHC-00122 maps to a region between residues 50 and 100 of human FAD-binding protein BRAF35-HDAC complex 110 kDa using the numbering given in entry BAA25527.1 (GeneID 23028).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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