Anti-RNF20 (IHC)

Anti-RNF20 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00100-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00100 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates... more
Product information "Anti-RNF20 (IHC)"
Protein function: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B, reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation. [The UniProt Consortium]
Keywords: Anti-RNF20, Anti-hBRE1, Anti-BRE1A, Anti-BRE1-A, Anti-RING finger protein 20, Anti-E3 ubiquitin-protein ligase BRE1A, Anti-RING-type E3 ubiquitin transferase BRE1A
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00100

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: mouse, rat, chicken, bovine, dog, horse, rabbit, guinea pig_10141, pig, panda, orangutan, monkey, gorilla, chimpanzee)
Immunogen: synthetic peptide. The epitope recognized by IHC-00100 maps to a region between residue 125 and 175 of human Ring Finger 20 using the numbering given in entry NP_062538.5 (GeneID 56254).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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