Anti-TPR (IHC)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00099-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00099 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Component of the nuclear pore complex (NPC), a complex required for the... more
Product information "Anti-TPR (IHC)"
Protein function: Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus, in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters, associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:22253824 and PubMed:11952838). Plays also a role as a structural and functional element of the perinuclear chromatin distribution, involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. [The UniProt Consortium]
Keywords: Anti-TPR, Anti-Megator, Anti-Nucleoprotein TPR, Anti-NPC-associated intranuclear protein, Anti-Translocated promoter region protein
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00099

Properties

Application: IHC, ICC-IF
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: bovine, dog, rabbit, pig, panda, monkey, gorilla, chimpanzee, northern white-cheeked gibbon, little brown bat)
Immunogen: synthetic peptide. The epitope recognized by IHC-00099 maps to a region between residue 2300 and the C-terminus (residue 2349) of human Translocated Promoter Region Protein using the numbering given in entryNP_003283.1 (GeneID 7175).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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