Anti-CCAR1 (IHC)

Anti-CCAR1 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00090-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00090 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Associates with components of the Mediator and p160 coactivator complexes that... more
Product information "Anti-CCAR1 (IHC)"
Protein function: Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation. May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938). [The UniProt Consortium]
Keywords: Anti-CARP1, Anti-CCAR1, Anti-CARP-1, Anti-Death inducer with SAP domain, Anti-Cell cycle and apoptosis regulatory protein 1, Anti-Cell division cycle and apoptosis regulator protein 1
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00090

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: rat, chicken, turkey, bovine, dog, horse, rabbit, guinea pig_10141, panda, orangutan, monkey, gorilla, chimpanzee)
Immunogen: synthetic peptide. The epitope recognized by IHC-00090 maps to a region between residue 1 and 50 of human Cell-Cycle and Apoptosis Regulatory Protein 1 using the numbering given in TrEMBL entry Q6X935 (GeneID 55749).
Format: Antigen Affinity Purified

Database Information

UniProt ID : Q8IX12 | Matching products
Gene ID GeneID 55749 | Matching products

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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