Anti-Rad50 (IHC)

Anti-Rad50 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00076-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00076 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Component of the MRN complex, which plays a central role in double-strand break... more
Product information "Anti-Rad50 (IHC)"
Protein function: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point (PubMed:11741547, PubMed:9590181, PubMed:9705271, PubMed:9651580). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). [The UniProt Consortium]
Keywords: Anti-RAD50, Anti-hRAD50, EC=3.6.-.-, Anti-DNA repair protein RAD50
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00076

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: bovine, dog, rabbit, orangutan, monkey, gorilla, chimpanzee, northern white-cheeked gibbon, little brown bat)
Immunogen: synthetic peptide. The epitope recognized by IHC-00076 maps to a region between residue 700 and 750 of human Rad50 using the numbering given in entry NP_005723.2 (GeneID 10111).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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