Anti-MDC1 (IHC)

Anti-MDC1 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00075-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00075 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Required for checkpoint mediated cell cycle arrest in response to DNA damage... more
Product information "Anti-MDC1 (IHC)"
Protein function: Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1. [The UniProt Consortium]
Keywords: Anti-MDC1, Anti-KIAA0170, Anti-Nuclear factor with BRCT domains 1, Anti-Mediator of DNA damage checkpoint protein 1
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00075

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: chimpanzee)
Immunogen: synthetic peptide. The epitope recognized by IHC-00075 maps to a region between residue 1350 and 1425 of human human Mediator of DNA Damage Checkpoint Protein 1 using the numbering given in entry NP_055456.1 (GeneID 9656).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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