Anti-Aurora A (IHC)

Anti-Aurora A (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00062-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00062 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Mitotic serine/threonine kinase that contributes to the regulation of cell... more
Product information "Anti-Aurora A (IHC)"
Protein function: Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis. [The UniProt Consortium]
Keywords: Anti-AIK, Anti-AURKA, Anti-ARK-1, Anti-hARK1, Anti-Aurora 2, EC=2.7.11.1, Anti-Aurora kinase A, Anti-Aurora-related kinase 1, Anti-Aurora/IPL1-related kinase 1, Anti-Breast tumor-amplified kinase, Anti-Serine/threonine-protein kinase 6
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00062

Properties

Application: ICC-IF
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: orangutan, gorilla, chimpanzee, northern white-cheeked gibbon)
Immunogen: synthetic peptide. The epitope recognized by IHC-00062 maps to a region between residue 75 and 125 of human Aurora A Kinase using the numbering given in entry NP_003591.2 (GeneID 6790).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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