Anti-INCENP (IHC)

Anti-INCENP (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00060-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00060 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Component of the chromosomal passenger complex (CPC), a complex that acts as a... more
Product information "Anti-INCENP (IHC)"
Protein function: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:15316025, PubMed:12925766, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin. Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). [The UniProt Consortium]
Keywords: Anti-INCENP, Anti-Inner centromere protein
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00060

Properties

Application: ICC-IF
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: synthetic peptide. The epitope recognized by IHC-00060 maps to a region between residue 325 and 400 of human Inner Centromere Protein using the numbering given in entry Q9NQS7 (GeneID 3619).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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