Anti-HDAC2 (IHC)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00057-T 10 µl (1 µg) -

2 - 8 business days*

164.00€
IHC-00057 100 µl (10 µg) -

2 - 8 business days*

623.00€
 
Protein function: Responsible for the deacetylation of lysine residues on the N-terminal part of... more
Product information "Anti-HDAC2 (IHC)"
Protein function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A. [The UniProt Consortium]
Keywords: Anti-HD2, Anti-HDAC2, EC=3.5.1.98, Anti-Histone deacetylase 2
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00057

Properties

Application: IHC, IHC-IF
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: orangutan, monkey, gorilla, chimpanzee, northern white-cheeked gibbon, white-tufted-ear marmoset, tasmanian devil)
Immunogen: synthetic peptide. The epitope recognized by IHC-00057 maps to a region between residue 425 and the C-terminus (residue 488) of human Histone Deacetylase 2 using the numbering given in entry NP_001518.1 (GeneID 3066).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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