Anti-CD31 (IHC)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00055-T 10 µl (1 µg) -

2 - 8 business days*

164.00€
IHC-00055 100 µl (10 µg) -

2 - 8 business days*

623.00€
 
Protein function: Induces susceptibility to atherosclerosis. Cell adhesion molecule which is... more
Product information "Anti-CD31 (IHC)"
Protein function: Induces susceptibility to atherosclerosis. Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC). [The UniProt Consortium]
Keywords: Anti-CD31, Anti-PECA1, Anti-PECAM1, Anti-GPIIA', Anti-EndoCAM, Anti-PECAM-1, Anti-Platelet endothelial cell adhesion molecule
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00055

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: synthetic peptide. The epitope recognized by IHC-00050 maps to a region between residue 700 and the C-terminus (residue 738) of human CD31 using the numbering given in entry NP_000433.2 (GeneID 5175).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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