Anti-CARM1 (IHC)

Anti-CARM1 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00045-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00045 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of... more
Product information "Anti-CARM1 (IHC)"
Protein function: Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg- 2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA- stabilizing properties and the half-life of their target mRNAs. [The UniProt Consortium]
Keywords: Anti-CARM1, Anti-PRMT4, Anti-Protein arginine N-methyltransferase 4, Anti-Histone-arginine methyltransferase CARM1, Anti-Coactivator-associated arginine methyltransferase 1
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00045

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: mouse, rat, bovine, dog, pig, orangutan, monkey, gorilla, naked mole rat, small-eared galago, northern white-cheeked gibbon)
Immunogen: synthetic peptide. The epitope recognized by IHC-00045 maps to a region between residue 550 and the C-terminus (residue 585) of human Coactivator-Associated Arginine Methyltransferase 1 using the numbering given in SwissProt entry Q86X55 (GeneID 10498).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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