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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
IHC-00042-T | 10 µl (5 µg) | - |
2 - 8 business days* |
164.00€
|
|||
IHC-00042 | 100 µl (50 µg) | - |
2 - 8 business days* |
623.00€
|
Protein function: Calcium/calmodulin-dependent protein kinase that operates in the... more
Product information "Anti-CamK4 (IHC)"
Protein function: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18. [The UniProt Consortium]
Keywords: | Anti-CAMK, Anti-CAMK4, Anti-CaMK IV, EC=2.7.11.17, Anti-CaM kinase-GR, Anti-Calcium/calmodulin-dependent protein kinase type IV |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | IHC-00042 |
Properties
Application: | IHC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human (Expected: gorilla, chimpanzee, northern white-cheeked gibbon, white-tufted-ear marmoset) |
Immunogen: | synthetic peptide. The epitope recognized by IHC-00042 maps to a region between residue 425 and the C-terminus (residue 473) of human Calcium/Calmodulin-dependent Protein Kinase IV using the numbering given in Swiss-Prot entry Q16566 (GeneID 814). |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K05869 | Matching products |
UniProt ID : | Q16566 | Matching products |
Gene ID | GeneID 814 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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