Anti-MTA1 (IHC)

Anti-MTA1 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00026-T 10 µl (5 µg) -

2 - 8 business days*

164.00€
IHC-00026 100 µl (50 µg) -

2 - 8 business days*

623.00€
 
Protein function: Transcriptional coregulator which can act as both a transcriptional corepressor... more
Product information "Anti-MTA1 (IHC)"
Protein function: Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator. As a part of the histone-deacetylase multiprotein complex (NuRD), regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA. In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A. Acts as a transcriptional coactivator of BCAS3, PAX5 and SUMO2, independent of the NuRD complex. Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3. Plays a role in the inflammatory responses, both as a target and as a component of the NF-kappa-B signaling and regulates a subset of proinflammatory cytokines such as IL1B, MIP2, and TNF. Regulates p53-dependent and -independent DNA repair processes following genotoxic stress. Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair. Plays an important role in tumorigenesis, tumor invasion, and metastasis. Involved in the epigenetic regulation of ESR1 expression in breast cancer in a TFAP2C, IFI16 and HDAC4/5/6-dependent manner. Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles. Positively regulates the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1. Regulates deacetylation of ARNTL/BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1- mediated transcription repression. Isoform Short binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses. [The UniProt Consortium]
Keywords: Anti-MTA1, Anti-Metastasis-associated protein MTA1
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00026

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: bovine, dog, horse, panda, orangutan, monkey, gorilla, northern white-cheeked gibbon, african elephant, ferret)
Immunogen: synthetic peptide. The epitope recognized by IHC-00026 maps to a region between residue 400 and 450 of human Metastasis Associated Protein 1 using the numbering given in SwissProt entry Q13330 (GeneID 9112).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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