Anti-EDD1 (IHC)

Anti-EDD1 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00025-T 10 µl (1 µg) -

2 - 8 business days*

164.00€
IHC-00025 100 µl (10 µg) -

2 - 8 business days*

623.00€
 
Protein function: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway.... more
Product information "Anti-EDD1 (IHC)"
Protein function: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'- linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes. [The UniProt Consortium]
Keywords: Anti-EDD, Anti-UBR5, Anti-hHYD, EC=2.3.2.26, Anti-Progestin-induced protein, Anti-E3 ubiquitin-protein ligase UBR5, Anti-Hyperplastic discs protein homolog, Anti-HECT-type E3 ubiquitin transferase UBR5, Anti-E3 ubiquitin-protein ligase
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00025

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: mouse, rat, X. tropicalis, chicken, turkey, bovine, dog, horse, pig, panda, orangutan, monkey, gorilla, chimpanzee)
Immunogen: synthetic peptide. The epitope recognized by IHC-00025 maps to a region between residue 600 and 650 of human E3 Ubiquitin Protein Ligase, HECT domain containing 1 using the numbering given in entry NP 056986.2 (GeneID 51366).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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