Anti-BRD8 (IHC)

Anti-BRD8 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00020-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00020 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: May act as a coactivator during transcriptional activation by hormone-activated... more
Product information "Anti-BRD8 (IHC)"
Protein function: May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1- like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. [The UniProt Consortium]
Keywords: Anti-SMAP, Anti-BRD8, Anti-p120, Anti-TrCP120, Anti-Bromodomain-containing protein 8, Anti-Skeletal muscle abundant protein, Anti-Skeletal muscle abundant protein 2, Anti-Thyroid hormone receptor coactivating protein of 120 kDa
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00020

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: rat, dog, horse, rabbit, guinea pig_10141, pig, panda, monkey, gorilla, naked mole rat, chinese hamster, little brown bat)
Immunogen: synthetic peptide. The epitope recognized by IHC-00020 maps to a region between residue 200 and 250 of human Bromodomain containing 8 using the numbering given in TrEMBL entry Q969M9 (GeneID 10902).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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