Anti-phospho-SMC1 (Ser966) (IHC)

Anti-phospho-SMC1 (Ser966) (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00016-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00016 100 µl (25 µg) -

2 - 8 business days*

665.00€
 
Protein function: Involved in chromosome cohesion during cell cycle and in DNA repair. Central... more
Product information "Anti-phospho-SMC1 (Ser966) (IHC)"
Protein function: Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. [The UniProt Consortium]
Keywords: Anti-phospho-SMC1A, Anti-phospho-Sb1.8, Anti-phospho-SMC-1A, Anti-phospho-DXS423E, Anti-phospho-SMC-1-alpha, Anti-phospho-SMC protein 1A, Anti-phospho-Structural maintenance of chromosomes protein 1A
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00016

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: orangutan, monkey, northern white-cheeked gibbon, small-eared galago, crab-eating macaque, white-tufted-ear marmoset)
Immunogen: synthetic peptide. Immunogen for IHC-00016 was a phosphorylated synthetic peptide, which represented a portion of human Structural Maintenance of Chromosomes 1 (GeneID 8243) around serine 966 according to the numbering given in entry NP_006297.2.
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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