Anti-EGFR (IHC)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00005-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00005 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Receptor tyrosine kinase binding ligands of the EGF family and activating... more
Product information "Anti-EGFR (IHC)"
Protein function: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS- RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Plays a role in enhancing learning and memory performance. [The UniProt Consortium]
Keywords: Anti-ERBB, Anti-EGFR, EC=2.7.10.1, Anti-Proto-oncogene c-ErbB-1, Anti-Epidermal growth factor receptor, Anti-Receptor tyrosine-protein kinase erbB-1
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00005

Properties

Application: IHC, IHC-IF
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: monkey, gorilla, chimpanzee, northern white-cheeked gibbon, crab-eating macaque, white-tufted-ear marmoset)
Immunogen: synthetic peptide. The epitope recognized by IHC-00005 maps to a region between residue 1150 and the C-terminus (residue 1210) of human Epidermal Growth Factor Receptor using the numbering given in SwissProt entry P00533 (GeneID 1956).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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