Anti-53BP1 (IHC)

Anti-53BP1 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00001-T 10 µl (1 µg) -

2 - 8 business days*

164.00€
IHC-00001 100 µl (10 µg) -

2 - 8 business days*

623.00€
 
Protein function: Double-strand break (DSB) repair protein involved in response to DNA damage,... more
Product information "Anti-53BP1 (IHC)"
Protein function: Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:22553214, PubMed:23333306, PubMed:17190600, PubMed:21144835, PubMed:28241136). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23727112, PubMed:23333306). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23760478, PubMed:28241136, PubMed:17190600). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates to the repair and the orientation of the broken DNA ends during CSR. In contrast, it is not required for classic NHEJ and V(D)J recombination. Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). [The UniProt Consortium]
Keywords: Anti-53BP1, Anti-p53BP1, Anti-p53-binding protein 1, Anti-TP53-binding protein 1
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00001

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse
Immunogen: synthetic peptide. The epitope recognized by IHC-00001 maps to a region between residue 350 and 400 of human tumor protein p53 binding protein 1 using the numbering given in entry NP_005648.1 (GeneID 7158).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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