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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
A302-994A-T | 10 µl (10 µg) | - |
2 - 8 business days* |
164.00€
|
|||
A302-994A | 100 µl (100 µg) | - |
2 - 8 business days* |
588.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA... more
Product information "Anti-RNF138"
Protein function: E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination (PubMed:26502055, PubMed:26502057). Recruited to sites of double- strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination (PubMed:26502055, PubMed:26502057). Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination (PubMed:26502055). According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP (PubMed:26502057). Together with NLK, involved in the ubiquitination and degradation of TCF/LEF (PubMed:16714285). Also exhibits auto-ubiquitination activity in combination with UBE2K (PubMed:16714285). May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (PubMed:16714285). [The UniProt Consortium]
Keywords: | Anti-hNARF, Anti-HSD-4, Anti-RING finger protein 138, Anti-NLK-associated RING finger protein, Anti-E3 ubiquitin-protein ligase RNF138, Anti-Nemo-like kinase-associated RING finger protein |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | A302-994A |
Properties
Application: | WB, IP |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human (Expected: bovine) |
Immunogen: | The epitope recognized by A302-994A maps to a region between residue 195 and 245 of human Ring Finger Protein 138 using the numbering given in entry NP_057355.2 (GeneID 51444). |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K10668 | Matching products |
UniProt ID : | Q8WVD3 | Matching products |
Gene ID | GeneID 51444 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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