Anti-WWP1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A302-949A-T	10 µl (10 µg)		-		2 - 8 business days*		164.00€
A302-949A	100 µl (100 µg)		-		2 - 8 business days*		588.00€

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Protein function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2... more

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Product information "Anti-WWP1"

Protein function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1, the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF. [The UniProt Consortium]

Keywords:	Anti-WWP1, Anti-AIP5, Anti-Tiul1, EC=2.3.2.26, Anti-WW domain-containing protein 1, Anti-Atrophin-1-interacting protein 5, Anti-TGIF-interacting ubiquitin ligase 1, Anti-HECT-type E3 ubiquitin transferase WWP1
Supplier:	Bethyl Laboratories
Supplier-Nr:	A302-949A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: chimpanzee, northern white-cheeked gibbon)
Immunogen:	synthetic peptide. The epitope recognized by A302-949A maps to a region between residue 200 and 250 of human WW Domain Containing E3 Ubiquitin Protein Ligase 1 using the numbering given in entry NP_008944.1 (GeneID 11059).
Format:	Antigen Affinity Purified