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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
A302-946A-T | 10 µl (2 µg) | - |
2 - 8 business days* |
164.00€
|
|||
A302-946A | 100 µl | - |
2 - 8 business days* |
588.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically... more
Product information "Anti-Synoviolin"
Protein function: Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130). Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130). Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation (PubMed:17141218). Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis (PubMed:17170702). Mediates the ubiquitination and subsequent degradation of cytoplasmic NFE2L1. [The UniProt Consortium]
Keywords: | Anti-HRD1, Anti-SYVN1, EC=2.3.2.27, Anti-Synovial apoptosis inhibitor 1, Anti-E3 ubiquitin-protein ligase synoviolin, Anti-RING-type E3 ubiquitin transferase synoviolin |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | A302-946A |
Properties
Application: | WB, IP |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse (Expected: rat, bovine, dog, horse, rabbit, swine, orangutan, rhesus monkey, chimpanzee, chinese hamster, naked mole rat, small-eared galago, thirteen-lined ground squirrel, little brown bat) |
Immunogen: | synthetic peptide. The epitope recognized by A302-946A maps to a region between residue 567 and 617 of human Synovial Apoptosis Inhibitor 1 using the numbering given in entry NP_757385.1 (GeneID 84447). |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K10601 | Matching products |
UniProt ID : | Q86TM6 | Matching products |
Gene ID | GeneID 84447 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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