Anti-OTUB1

Anti-OTUB1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-917A-T 10 µl (2 µg) -

2 - 8 business days*

164.00€
A302-917A 100 µl -

2 - 8 business days*

588.00€
 
Protein function: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin... more
Product information "Anti-OTUB1"
Protein function: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes anergy. Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). Mediates deubiquitination of 'Lys- 48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains. Not able to cleave di-ubiquitin. Also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to 'Lys-48'-linked ubiquitin. [The UniProt Consortium]
Keywords: Anti-OTB1, Anti-hOTU1, Anti-OTUB1, Anti-HSPC263, Anti-Otubain-1, Anti-Ubiquitin thioesterase OTUB1, Anti-Deubiquitinating enzyme OTUB1, Anti-Ubiquitin-specific-processing protease OTUB1, Anti-OTU domain-containing ubiquitin aldehyde-binding protein 1
Supplier: Bethyl Laboratories
Supplier-Nr: A302-917A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: rat)
Immunogen: synthetic peptide. The epitope recognized by A302-917A maps to a region between residue 1 and 40 of human OTU Domain, Ubiquitin Aldehyde Binding 1 using the numbering given in entry NP_060140.2 (GeneID 55611).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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