Anti-MGRN1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A302-912A-T	10 µl (2 µg)		-		2 - 8 business days*		164.00€
A302-912A	100 µl		-		2 - 8 business days*		588.00€

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Protein function: E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of... more

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Product information "Anti-MGRN1"

Protein function: E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to- lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling. [The UniProt Consortium]

Keywords:	Anti-MGRN1, Anti-KIAA0544, EC=2.3.2.27, Anti-RING finger protein 156, Anti-Mahogunin RING finger protein 1, Anti-E3 ubiquitin-protein ligase MGRN1, Anti-RING-type E3 ubiquitin transferase MGRN1
Supplier:	Bethyl Laboratories
Supplier-Nr:	A302-912A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: orangutan, rhesus monkey, gorilla, chimpanzee, crab-eating macaque, northern white-cheeked gibbon)
Immunogen:	synthetic peptide. The epitope recognized by A302-912A maps to a region between residue 400 and 450 of human Mahogunin, Ring Finger 1 using the numbering given in entry NP_001135761.1 (GeneID 23295).
Format:	Antigen Affinity Purified