Anti-KLHL12

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A302-910A-T	10 µl (10 µg)		-		2 - 8 business days*		164.00€
A302-910A	100 µl (100 µg)		-		2 - 8 business days*		588.00€

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Protein function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex... more

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Product information "Anti-KLHL12"

Protein function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport (PubMed:22358839, PubMed:27565346). The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B) (PubMed:22358839, PubMed:27565346). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3 (PubMed:16547521). The BCR(KLHL12) complex also mediates polyubiquitination of DRD4, without leading to degradation of DRD4 (PubMed:18303015, PubMed:20100572). [The UniProt Consortium]

Keywords:	Anti-C3IP1, Anti-hDKIR, Anti-KLHL12, Anti-DKIR homolog, Anti-Kelch-like protein 12, Anti-CUL3-interacting protein 1
Supplier:	Bethyl Laboratories
Supplier-Nr:	A302-910A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: mouse, rat, bovine)
Immunogen:	synthetic peptide. The epitope recognized by A302-910A maps to a region between residue 150 and 200 of human Kelch-Like 12 using the numbering given in entry NP_067646.1 (GeneID 59349).
Format:	Antigen Affinity Purified