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Anti-NEDD4L

ART NR.: A302-512A-T (20 µl / 2 blots)
A302-512A-M (100 µl / 10 blots)
A302-512A (100 µl / 20 µg)

Hersteller: Bethyl

Datenblatt

Anwendungen: WB, IP

Format: antigen affinity purified

Wirt: Rabbit

Isotyp: IgG

Reaktivität: human, mouse (expected: bovine, rabbit, swine, panda, orangutan, rhesus monkey, gorilla, chimpanzee, white-tufted-ear marmoset, crab-eating macaque, small-eared galago, little brown bat, northern white-cheeked gibbon)

Immunogen: synthetic peptide. The epitope recognized by A302-512A maps to a region between residue 225 and 275 of human neural precursor cell expressed, developmentally down-regulated 4-like using the numbering given in entry NP_001138439.1 (GeneID 23327).

Lagerung: +4°C

Versand: +4°C

UniProt ID: Q96PU5 | Suche mit UniProt ID

Gene ID: Gene ID 23327 | Suche mit Gene ID

KEGG ID: K13305 | Suche mit KEGG ID

Schlagworte: EC=6.3.2.-, Anti-NEDD4L, Anti-neural precursor cell expressed, Anti-developmentally down-regulated 4-like, Anti-RSP5.

A302-512A-T

20 µl (2 blots)

57 €

A302-512A-M

100 µl (10 blots)

260 €

A302-512A

100 µl (20 µg)

356 €

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Bemerkungen: NEDD4L (neural precursor cell expressed, developmentally down-regulated 4-like) functions as an E3 ubiquitin-protein ligase. NEDD4L inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. It also promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Alternative names for NEDD4L include ubiquitin-protein ligase Rsp5, Nedd4-2, Nedd4.2, NEDL3, and KIAA0439.

Spezifikationen

NEDD4L Antibody

Rabbit anti-NEDD4L Antibody, Affinity Purified
NEDD4L Antibody

Gene and Protein Information

Citations

Tanksley JP, NEDD4L Is Downregulated in Colorectal Cancer and Inhibits Canonical WNT Signaling. PLoS One. 2013 Nov 28;8(11):e81514. WB
PubMed: 24312311

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