Anti-HERC2

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A301-905A-T	10 µl (10 µg)		-		2 - 8 business days*		164.00€
A301-905A	100 µl (100 µg)		-		2 - 8 business days*		588.00€

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Protein function: E3 ubiquitin-protein ligase that regulates ubiquitin- dependent retention of... more

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Product information "Anti-HERC2"

Protein function: E3 ubiquitin-protein ligase that regulates ubiquitin- dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. [The UniProt Consortium]

Keywords:	Anti-E3 ubiquitin-protein ligase HERC2, Anti-HECT-type E3 ubiquitin transferase HERC2, Anti-HECT domain and RCC1-like domain-containing protein 2
Supplier:	Bethyl Laboratories
Supplier-Nr:	A301-905A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse (Expected: rat, zebrafish, X. tropicalis, chicken, turkey, bovine, dog, horse, rabbit, guinea pig, swine, panda, rhesus monkey, gorilla, chimpanzee, west indian ocean coelacanth, nile tilapia, spotted green pufferfish)
Immunogen:	synthetic peptide. The epitope recognized by A301-905A maps to a region between residue 4784 and 4834 of human hect domain and RLD 2 using the numbering given in entry NP_004658.3 (GeneID 8924).
Format:	Antigen Affinity Purified