Anti-UFD1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A301-875A-T	10 µl (2 µg)		-		2 - 8 business days*		164.00€
A301-875A	100 µl		-		2 - 8 business days*		588.00€

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Protein function: Essential component of the ubiquitin-dependent proteolytic pathway which... more

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Product information "Anti-UFD1"

Protein function: Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures. Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729). [The UniProt Consortium]

Keywords:	Anti-UFD1L, Anti-UB fusion protein 1, Anti-Ubiquitin fusion degradation protein 1, Anti-Ubiquitin recognition factor in ER-associated degradation protein 1
Supplier:	Bethyl Laboratories
Supplier-Nr:	A301-875A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: dog, horse, guinea pig, panda, orangutan, rhesus monkey, gorilla, chimpanzee, crab-eating macaque, european domestic ferret, naked mole rat, thirteen-lined ground squirrel, little brown bat, northern white-cheeked gibbon)
Immunogen:	synthetic peptide. The epitope recognized by A301-875A maps to a region between residue 175 and 225 of human ubiquitin fusion degradation 1 using the numbering given in entry NP_005650.2 (GeneID 7353).
Format:	Antigen Affinity Purified