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Anti-FBW7

ART NR.: A301-721A-T (10 µl | 10 µg)
A301-721A (100 µl | 100 µg)

Hersteller: Bethyl

Datenblatt



MSDS

Anwendungen: IP, IHC-​P, IF

Format: antigen affinity purified

Wirt: Rabbit

Isotyp: IgG

Reaktivität: human (expected: rhesus monkey, gorilla, chimpanzee, crab-eating macaque, northern white-cheeked gibbon)

Immunogen: synthetic peptide. The epitope recognized by A301-721A-T maps to a region between residue 50 and 100 of human F-box and WD-40 domain protein 7 using the numbering given in entry NP_361014.1 (GeneID 55294).

Lagerung: +4°C

Versand: +4°C

UniProt ID: Q969H0 | Suche mit UniProt ID

Gene ID: Gene ID 55294 | Suche mit Gene ID

KEGG ID: K10260 | Suche mit KEGG ID

Schlagworte: Anti-hAgo, Anti-hCdc4, Anti-SEL-10, Anti-F-box protein FBX30, Anti-Archipelago homolog, Anti-F-box/WD repeat-containing protein 7, Anti-F-box and WD-40 domain-containing protein 7

A301-721A-T

10 µl (10 µg)

61 €

A301-721A

100 µl (100 µg)

385 €

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Bemerkungen: FBW7 (F-box and WD repeat domain containing 7) is a member of the F-box family of proteins. The F-box is a protein-protein interaction motif first identified in cyclin F. F-box proteins associate with SCFs (Skp1-cullin-F-box protein ligase complexes) which are E3 ligases that ubiquitinate proteins and target them for proteasomal degradation. FBW7 has been found to bind and specifically target cyclin E and the Notch intracellular domain (NICD) for ubiquitination. Defects in FBW7 may contribute to tumorigenesis. Alternate names for FBW7 include F-box protein FBX30, hCdc4, archipelago homolog, hAgo, SEL-10, FBXW7, and FBXO30.

Spezifikationen

FBW7 Antibody

Rabbit anti-FBW7 Antibody, Affinity Purified
FBW7 AntibodyFBW7 Antibody
FBW7 AntibodyFBW7 Antibody

Gene and Protein Information

Citations

Li Z, p53 Mutation Directs AURKA Overexpression via miR-25 and FBXW7 in Prostatic Small Cell Neuroendocrine Carcinoma. Mol Cancer Res. 2014 Dec 15. pii: molcanres.0277.2014. WB
PubMed: 25512615
Sancho R, Loss of Fbw7 Reprograms Adult Pancreatic Ductal Cells into α, δ, and β Cells. Cell Stem Cell. 2014 Aug 7;15(2):139-53. WB
PubMed: 25105579
Welcker M, Fbw7 dimerization determines the specificity and robustness of substrate degradation. Genes Dev. 2013 Dec 1;27(23):2531-6.
PubMed: 24298052
Bengoechea-Alonso MT et al., The ubiquitin ligase Fbxw7 controls adipocyte differentiation by targeting C/EBPalpha for degradation. Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11817-22. WB
PubMed: 20534483

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