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ART NR.: A301-721A (100 µl)

Hersteller: Bethyl


Anwendungen: IP

Format: antigen affinity purified

Wirt: Rabbit

Isotyp: IgG

Reaktivität: human (expected: rhesus monkey, gorilla, chimpanzee, crab-eating macaque, northern white-cheeked gibbon)

Immunogen: synthetic peptide. The epitope recognized by A301-721A maps to a region between residue 50 and 100 of human F-box and WD-40 domain protein 7 using the numbering given in entry NP_361014.1 (GeneID 55294).

Lagerung: +4°C

Versand: +4°C

UniProt ID: Q969H0 | Suche mit UniProt ID

KEGG ID: K10260 | Suche mit KEGG ID

Schlagworte: Anti-FBW7, Anti-FBXW7, Anti-F-box and WD-40 domain protein 7, Anti-Archipelago, Anti-SEL10, Anti-SEL-10.


100 µl

356 €

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Bemerkungen: FBW7 (F-box and WD repeat domain containing 7) is a member of the F-box family of proteins. The F-box is a protein-protein interaction motif first identified in cyclin F. F-box proteins associate with SCFs (Skp1-cullin-F-box protein ligase complexes) which are E3 ligases that ubiquitinate proteins and target them for proteasomal degradation. FBW7 has been found to bind and specifically target cyclin E and the Notch intracellular domain (NICD) for ubiquitination. Defects in FBW7 may contribute to tumorigenesis. Alternate names for FBW7 include F-box protein FBX30, hCdc4, archipelago homolog, hAgo, SEL-10, FBXW7, and FBXO30.


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