Kontakt 0800-2466651 DE | EN Merkliste Login Warenkorb
Suche
zurück

Anti-FBW7

ART NR.: A301-721A-T (10 µl / 10 µg)
A301-721A (100 µl / 100 µg)

Hersteller: Bethyl

Datenblatt

Anwendungen: IP

Format: antigen affinity purified

Wirt: Rabbit

Isotyp: IgG

Reaktivität: human (expected: rhesus monkey, gorilla, chimpanzee, crab-eating macaque, northern white-cheeked gibbon)

Immunogen: synthetic peptide. The epitope recognized by A301-721A maps to a region between residue 50 and 100 of human F-box and WD-40 domain protein 7 using the numbering given in entry NP_361014.1 (GeneID 55294).

Lagerung: +4°C

Versand: +4°C

UniProt ID: Q969H0 | Suche mit UniProt ID

KEGG ID: K10260 | Suche mit KEGG ID

Schlagworte: Anti-FBW7, Anti-FBXW7, Anti-F-box and WD-40 domain protein 7, Anti-Archipelago, Anti-SEL10, Anti-SEL-10.

A301-721A-T

10 µl (10 µg)

57 €

A301-721A

100 µl (100 µg)

356 €

Größe wählen:
In Warenkorb aufnehmen


Bemerkungen: FBW7 (F-box and WD repeat domain containing 7) is a member of the F-box family of proteins. The F-box is a protein-protein interaction motif first identified in cyclin F. F-box proteins associate with SCFs (Skp1-cullin-F-box protein ligase complexes) which are E3 ligases that ubiquitinate proteins and target them for proteasomal degradation. FBW7 has been found to bind and specifically target cyclin E and the Notch intracellular domain (NICD) for ubiquitination. Defects in FBW7 may contribute to tumorigenesis. Alternate names for FBW7 include F-box protein FBX30, hCdc4, archipelago homolog, hAgo, SEL-10, FBXW7, and FBXO30.

Spezifikationen

FBW7 Antibody

Rabbit anti-FBW7 Antibody, Affinity Purified
FBW7 AntibodyFBW7 Antibody
FBW7 AntibodyFBW7 Antibody

Gene and Protein Information

Citations

Li Z, p53 Mutation Directs AURKA Overexpression via miR-25 and FBXW7 in Prostatic Small Cell Neuroendocrine Carcinoma. Mol Cancer Res. 2014 Dec 15. pii: molcanres.0277.2014. WB
PubMed: 25512615
Sancho R, Loss of Fbw7 Reprograms Adult Pancreatic Ductal Cells into ?, ?, and ? Cells. Cell Stem Cell. 2014 Aug 7;15(2):139-53. WB
PubMed: 25105579
Welcker M, Fbw7 dimerization determines the specificity and robustness of substrate degradation. Genes Dev. 2013 Dec 1;27(23):2531-6.
PubMed: 24298052
Bengoechea-Alonso MT et al., The ubiquitin ligase Fbxw7 controls adipocyte differentiation by targeting C/EBPalpha for degradation. Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11817-22. WB
PubMed: 20534483

Verwandte Produkte

    Products for: FBXW7, SEL10 - F-box and WD-40 domain protein 7

    Die Preise für Antikörper verstehen sich exkl. Versandkosten, eventuell anfallender Kühlmittelpauschale sowie der jeweils geltenden Mehrwertsteuer.



    Cut Your Validation Time in HalfBiomol sucht den SuperantikörperArigo Antibody Duos

     Recombinant Monoclonal Antibodies from a Non-Animal SourceAntibody GuaranteeEasy Antibody Conjugation alle Treffer anzeigen (257 INFOS)

     


    Forschungsprodukte im Fokus
     
    Produkte
    Service
    Company
    € 10 Gutschein sichern