Anti-USP10

Item number Size Datasheet Manual SDS Delivery time Quantity Price
A300-900A-T 10 µl (2 µg) -

2 - 8 business days*

164.00€
A300-900A 100 µl -

2 - 8 business days*

588.00€
 
Protein function: Hydrolase that can remove conjugated ubiquitin from target proteins such as... more
Product information "Anti-USP10"
Protein function: Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34- containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). [The UniProt Consortium]
Keywords: Anti-USP10, Anti-KIAA0190, Anti-Ubiquitin thioesterase 10, Anti-Deubiquitinating enzyme 10, Anti-Ubiquitin carboxyl-terminal hydrolase 10, Anti-Ubiquitin-specific-processing protease 10
Supplier: Bethyl Laboratories
Supplier-Nr: A300-900A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: orangutan, rhesus monkey, white-tufted-ear marmoset, crab-eating macaque, northern white-cheeked gibbon)
Immunogen: synthetic peptide. The epitope recognized by A300-900A maps to a region between residue 50 and 100 of human Ubiquitin Specific Peptidase 10 using the numbering given in entry NP_005144.1 (GeneID 9100).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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