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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
A300-555A-T | 10 µl (10 µg) | - |
2 - 8 business days* |
164.00€
|
|||
A300-555A | 100 µl (100 µg) | - |
2 - 8 business days* |
588.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit... more
Product information "Anti-GCN2"
Protein function: Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' in response to low amino acid availability (PubMed:25329545). Plays a role as an activator of the integrated stress response (ISR) required for adapatation to amino acid starvation. Converts phosphorylated eIF- 2-alpha/EIF2S1 either to a competitive inhibitor of the translation initiation factor eIF-2B, leading to a global protein synthesis repression, and thus to a reduced overall utilization of amino acids, or to a translational initiation activation of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Binds uncharged tRNAs. Involved in cell cycle arrest by promoting cyclin D1 mRNA translation repression after the unfolded protein response pathway (UPR) activation or cell cycle inhibitor CDKN1A/p21 mRNA translation activation in response to amino acid deprivation (PubMed:26102367). Plays a role in the consolidation of synaptic plasticity, learning as well as formation of long-term memory. Plays a role in neurite outgrowth inhibition. Plays a proapoptotic role in response to glucose deprivation. Promotes global cellular protein synthesis repression in response to UV irradiation independently of the stress- activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and p38 MAPK signaling pathways. Plays a role in the antiviral response against alphavirus infection, impairs early viral mRNA translation of the incoming genomic virus RNA, thus preventing alphavirus replication. [The UniProt Consortium]
Keywords: | Anti-GCN2, Anti-GCN2-like protein, Anti-eIF-2-alpha kinase GCN2, Anti-Eukaryotic translation initiation factor 2-alpha kinase 4 |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | A300-555A |
Properties
Application: | WB, IP |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human (Expected: bovine, dog, horse, rabbit, orangutan, rhesus monkey, gorilla, chimpanzee, crab-eating macaque) |
Immunogen: | synthetic peptide. The epitope recognized by A300-555A maps to a region between residues 1 and 50 of human GCN2 (eIF2AK4, eukaryotic translation initiation factor 2 alpha kinase 4) using the numbering given in entry NP_001013725.2 (GeneID 440275). |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K16196 | Matching products |
UniProt ID : | Q9P2K8 | Matching products |
Gene ID | GeneID 440275 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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