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Anti-E6AP

ART NR.: A300-352A (100 µl | 100 µg)

Hersteller: Bethyl

Datenblatt

Anwendungen: WB, IP

Format: antigen affinity purified

Wirt: Rabbit

Isotyp: IgG

Reaktivität: human, mouse (expected: X. laevis, X. tropicalis, chicken, turkey, rabbit, guinea pig, swine, panda, orangutan, rhesus monkey, gorilla, chimpanzee, medaka fish, percoidei, cichlidae, nile tilapia, japanese sea perch, barramundi, siniperca kneri)

Immunogen: synthetic peptide. The epitope recognized by A300-352A maps to a region between residue 400 and 450 of human Ubiquitin Protein Ligase E3A using the numbering given in entry NP_000453.2 (GeneID 7337).

Lagerung: +4°C

Versand: +4°C

UniProt ID: Q05086 | Suche mit UniProt ID

KEGG ID: K10587 | Suche mit KEGG ID

Schlagworte: EC=6.3.2.-, Anti-E6AP, Anti-HPVE6AP, Anti-EPVE6AP, Anti-Human papillomavirus E6-associated protein, Anti-UBE3A, Anti-Ubiquitin-protein ligase E3A, Anti-AS, Anti-Angelman Syndrome, Anti-ANCR.

A300-352A

100 µl (100 µg)

385 €

In Warenkorb aufnehmen


Bemerkungen: E6AP is an E3 ubiquitin ligase. Inheritance of a mutant maternal copy of this gene results in Angelman syndrome (AS) which is characterized by severe mental retardation, seizures, ataxia, and EEG abnormalities. E6AP interacts with the type 16 and 18 human papillomavirus E6 oncoprotein which results in the targeting of p53 for degradation via the ubiquitin-proteasome system. Alternate names for E6AP include ubiquitin-protein ligase E3A, E6AP ubiquitin-protein ligase, oncogenic protein-associated protein E6-AP, human papillomavirus E6-associated protein, renal carcinoma antigen NY-REN-54, UBE3A, E6AP, EPVE6AP, HPVE6A, AS, ANCR, and FLJ26981.

Spezifikationen

E6AP Antibody

Rabbit anti-E6AP Antibody, Affinity Purified
E6AP Antibody

Gene and Protein Information

Citations

Meng L, Towards a therapy for Angelman syndrome by targeting a long non-coding RNA. Nature. 2014 Dec 1. IHC-P
PubMed: 25470045
Holloway A, Resistance to UV-induced apoptosis by ?-HPV5 E6 involves targeting of activated BAK for proteolysis by recruitment of the HERC1 ubiquitin ligase. Int J Cancer. 2014 Nov 19. WB
PubMed: 25408501
Pignatelli M, Changes in mGlu5 Receptor-Dependent Synaptic Plasticity and Coupling to Homer Proteins in the Hippocampus of Ube3A Hemizygous Mice Modeling Angelman Syndrome. J Neurosci. 2014 Mar 26;34(13):4558-66. WB
PubMed: 24672001
Filonova I, Activity-dependent changes in MAPK activation in the Angelman Syndrome mouse model. Learn Mem. 2014 Jan 16;21(2):98-104. WB
PubMed: 24434871
Meng L, Truncation of Ube3a-ATS Unsilences Paternal Ube3a and Ameliorates Behavioral Defects in the Angelman Syndrome Mouse Model. PLoS Genet. 2013 Dec;9(12):e1004039. WB
PubMed: 24385930
Condon KH, The Angelman Syndrome Protein Ube3a/E6AP Is Required for Golgi Acidification and Surface Protein Sialylation. J Neurosci. 2013 Feb 27;33(9):3799-814. WB, IHC-P
PubMed: 23447592
Daily J et al., Spatial and temporal silencing of the human maternal UBE3A gene. Eur J Paediatr Neurol. 2012 Nov;16(6):587-91. WB
PubMed: 22560727
Meng L etc., Ube3a-ATS is an atypical RNA polymerase II transcript that represses the paternal expression of Ube3a. Hum Mol Genet. 2012 Jul 1;21(13):3001-12.
PubMed: 22493002
Daily JL et al., Adeno-associated virus-mediated rescue of the cognitive defects in a mouse model for Angelman syndrome. PLoS One. 2011;6(12):e27221. IHC-P
PubMed: 22174738
Ramamoorthy S et al., Isoform-specific degradation of PR-B by E6-AP is critical for normal mammary gland development. Mol Endocrinol. 2010 Nov;24(11):2099-113. WB
PubMed: 20829392
Sato M et al., Genomic imprinting of experience-dependent cortical plasticity by the ubiquitin ligase gene Ube3a. Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5611-6. WB, ICC
PubMed: 20212164
Reelfs O et al., Thiothymidine plus low-dose UVA kills hyperproliferative human skin cells independently of their human papilloma virus status. Mol Cancer Ther. 2007 Sep;6(9):2487-95. WB
PubMed: 17876046
Wu MY et al., Deficiency of Rbbp1/Arid4a and Rbbp1l1/Arid4b alters epigenetic modifications and suppresses an imprinting defect in the PWS/AS domain. Genes Dev. 2006 Oct 15;20(20):2859-70. WB
PubMed: 17043311
Jiang YH et al., A mixed epigenetic/genetic model for oligogenic inheritance of autism with a limited role for UBE3A. Am J Med Genet A. 2004 Nov 15;131(1):1-10.
PubMed: 15389703
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