Anti-BARD1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A300-263A-T	10 µl (10 µg)		-		2 - 8 business days*		164.00€
A300-263A	100 µl (100 µg)		-		2 - 8 business days*		588.00€

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Protein function: E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates... more

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Product information "Anti-BARD1"

Protein function: E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage. [The UniProt Consortium]

Keywords:	Anti-BARD1, Anti-BARD-1, Anti-BRCA1-associated RING domain protein 1, Anti-RING-type E3 ubiquitin transferase BARD1
Supplier:	Bethyl Laboratories
Supplier-Nr:	A300-263A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: rhesus monkey, chimpanzee, white-tufted-ear marmoset, crab-eating macaque, northern white-cheeked gibbon)
Immunogen:	synthetic peptide. The epitope recognized by A300-263A maps to a region between residues 250 and 300 of human BRCA1-associated RING Domain 1 using the numbering given in entry NP_000456.1 (GeneID 580).
Format:	Antigen Affinity Purified