Anti-CSN7b

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A300-044A-T	10 µl (10 µg)		-		2 - 8 business days*		164.00€
A300-044A	100 µl (100 µg)		-		2 - 8 business days*		588.00€

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Protein function: Component of the COP9 signalosome complex (CSN), a complex involved in various... more

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Product information "Anti-CSN7b"

Protein function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. [The UniProt Consortium]

Keywords:	Anti-CSN7B, Anti-SGN7b, Anti-COPS7B, Anti-Signalosome subunit 7b, Anti-COP9 signalosome complex subunit 7b, Anti-JAB1-containing signalosome subunit 7b
Supplier:	Bethyl Laboratories
Supplier-Nr:	A300-044A

Properties

Application:	WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: mouse, bovine)
Immunogen:	synthetic peptide. The epitope recognized by A300-044A maps to a region between residue 225 and the C-terminus (residue 264) of human constitutive photomorphogenic homolog subunit 7B using the numbering given in TrEMBL entry Q9H9Q2 (GeneID 64708).
Format:	Antigen Affinity Purified